Synthesis of chalcone derivatives as potential anti-diabetic agents.

  title={Synthesis of chalcone derivatives as potential anti-diabetic agents.},
  author={Chi-Ting Hsieh and T Hsieh and Mohamed El-Shazly and D W Chuang and Yi-Hong Tsai and C H Yen and Shou-Fang Wu and Yang-Chang Wu and F. -H. Chang},
  journal={Bioorganic & medicinal chemistry letters},
  volume={22 12},
Chalcones bearing electron donating or electron withdrawing substitutions were prepared and their glucose uptake activity was evaluated. Chalcone derivatives were synthesized in one step protocol with high purity and yield. Chalcones with chloro, bromo, iodo and hydroxy substitutions at position 2 on A-ring exhibited the highest activity with glucose medium concentration (210 to 236 mg/dl) compared to pioglitazone and rosiglitazone (230 and 263 mg/dl, respectively). Also chalcones with iodo… CONTINUE READING

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