Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins.

Abstract

Glycan recognition by lectins initiates clinically relevant processes such as toxin binding or tumor spread. Thus, the development of potent inhibitors has a medical perspective. Toward this goal, we report the synthesis of both rigid and flexible bivalent lactosides on scaffolds that include secondary and tertiary terephthalamides and N,N… (More)
DOI: 10.1021/jo901667r

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@article{Leyden2009SynthesisOB, title={Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins.}, author={Rosaria Leyden and Trinidad Velasco-Torrijos and Sabine Andr{\'e} and S{\'e}bastien G. Gouin and Hans-Joachim Gabius and Paul V Murphy}, journal={The Journal of organic chemistry}, year={2009}, volume={74 23}, pages={9010-26} }