Synthesis of bis-netropsin-linked hydroxamic acids and their DNA cleavage properties in the presence of transition or lanthanide metal ions.

Abstract

Nobel hydroxamic acids containing bis-netropsin units coupled by polymethylenetether (BNHA) have been synthesized. BNHA-ferrous complexes sequence-specifically cleaved pBR322 DNA fragment whereas corresponding cerium complexes showed low-sequence specific cleavage pattern.

Cite this paper

@article{Hashimoto1997SynthesisOB, title={Synthesis of bis-netropsin-linked hydroxamic acids and their DNA cleavage properties in the presence of transition or lanthanide metal ions.}, author={Shu Hashimoto and Kozuyoshi Itai and Yasuo Takeuchi and Yuji Nakamura}, journal={Nucleic acids symposium series}, year={1997}, volume={37}, pages={7-8} }