Synthesis of biomimetic precursors of isovelleral analogues.

@article{Rme2008SynthesisOB,
  title={Synthesis of biomimetic precursors of isovelleral analogues.},
  author={Daniel R{\"o}me and Erwan Arzel and Martin H Johansson and Olov Sterner},
  journal={Arkivoc},
  year={2008},
  volume={6},
  pages={91-99}
}
Based on how the mushroom Lactarius vellereus converts an inactive precursor into the cytotoxic dialdehyde isovelleral (1) via a cyclic enol ether, as part of a binary chemical defense system that protects the fruit bodies against parasites, a synthetic way to obtain analogous dialdehydes masked in the same way has been developed. As isovelleral analogues (e.g. 2 and 3) possess extremely potent cytotoxic activity, but display low selectivity as their biological activity is linked to their… Expand

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