Synthesis of beta2 glycoprotein 1 by the human placenta.

  title={Synthesis of beta2 glycoprotein 1 by the human placenta.},
  author={Lawrence W Chamley and Julian Allen and Peter W M Johnson},
  volume={18 5-6},
Autoantibodies to negatively charged phospholipids (aPL) can cause fetal loss, including recurrent miscarriage and stillbirth. The immunopathogenic mechanism by which this occurs is unknown, but these antibodies are known to bind phospholipid via a protein cofactor, beta2 glycoprotein 1. This protein is localized on placental syncytiotrophoblast and enables the binding of aPL from maternal blood. In this study, reverse transcription and the polymerase chain reaction (RT-PCR) was used on mRNA… CONTINUE READING
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