Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation.

  title={Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation.},
  author={Indyah Sulistyo Arty and Hendrik Timmerman and M Samhoedi and Sastrohamidjojo and Sugiyanto and Henk van der Goot},
  journal={European journal of medicinal chemistry},
  volume={35 4},
A series of benzylideneacetophenone derivatives have been synthesized and found to show potent inhibition of the lipid peroxidation (LPO) in rat liver microsomes. All 19 compounds prepared in this series are LPO inhibitors. The highest activity was found in para hydroxy derivatives with two meta tert-butyl substituents. 
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