Synthesis of argentatin A derivatives as growth inhibitors of human cancer cell lines in vitro.

@article{ParraDelgado2005SynthesisOA,
  title={Synthesis of argentatin A derivatives as growth inhibitors of human cancer cell lines in vitro.},
  author={Hortensia Parra-Delgado and T. Ram{\'i}rez-{\'A}pan and M. Mart{\'i}nez-V{\'a}zquez},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 4},
  pages={
          1005-8
        }
}
  • Hortensia Parra-Delgado, T. Ramírez-Ápan, M. Martínez-Vázquez
  • Published 2005
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • The syntheses of nine argentatin A analogs are described. These compounds were assessed for their ability to inhibit growth in vitro in four human cancer cell lines. Our results showed that the presence of either a double bond at C-1/C-2, or a bromine atom or formyl moiety at C-2 as well as the presence of an isoxazol ring in argentatin A enhanced its potency in all cell lines tested. In addition, an X-ray study of (16S,17R,20S,24R)-3-oxime-20,24-epoxy-16,25-dihydroxy-cycloartan-3-one led to… CONTINUE READING
    8 Citations

    Topics from this paper

    Chapter 2 – Terpenes
    • 2

    References

    SHOWING 1-10 OF 14 REFERENCES
    Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
    • 2,519
    Anti-angiogenic activity of triterpene acids.
    • 145
    Cytotoxic triterpenoids from the leaves of Euphorbia pulcherrima.
    • 41
    • PDF
    Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare.
    • 23
    Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids
    • 67