Synthesis of argentatin A derivatives as growth inhibitors of human cancer cell lines in vitro.
@article{ParraDelgado2005SynthesisOA, title={Synthesis of argentatin A derivatives as growth inhibitors of human cancer cell lines in vitro.}, author={Hortensia Parra-Delgado and T. Ram{\'i}rez-{\'A}pan and M. Mart{\'i}nez-V{\'a}zquez}, journal={Bioorganic & medicinal chemistry letters}, year={2005}, volume={15 4}, pages={ 1005-8 } }
The syntheses of nine argentatin A analogs are described. These compounds were assessed for their ability to inhibit growth in vitro in four human cancer cell lines. Our results showed that the presence of either a double bond at C-1/C-2, or a bromine atom or formyl moiety at C-2 as well as the presence of an isoxazol ring in argentatin A enhanced its potency in all cell lines tested. In addition, an X-ray study of (16S,17R,20S,24R)-3-oxime-20,24-epoxy-16,25-dihydroxy-cycloartan-3-one led to… CONTINUE READING
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