Synthesis of arborane triterpenols by a bacterial oxidosqualene cyclase

@article{Banta2016SynthesisOA,
  title={Synthesis of arborane triterpenols by a bacterial oxidosqualene cyclase},
  author={A. Banta and Jeremy H. Wei and Clare C. C. Gill and J. Giner and P. Welander},
  journal={Proceedings of the National Academy of Sciences},
  year={2016},
  volume={114},
  pages={245 - 250}
}
Significance Polycyclic lipids produced by bacteria and eukaryotes can be preserved in sedimentary rocks for millions of years. These ancient lipids can function as “molecular fossils” or biomarkers that can inform us about the types of organisms and environments on early Earth. However, proper interpretation of these biomarkers requires a comprehensive understanding of the taxonomic distribution, biosynthesis, and physiological function of these lipids in modern organisms. In this study, we… Expand
C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol synthesis
Deciphering the evolutionary history of microbial cyclic triterpenoids.
  • P. Welander
  • Biology, Medicine
  • Free radical biology & medicine
  • 2019
Origin and Evolution of Polycyclic Triterpene Synthesis
Evolution of bacterial steroid biosynthesis and its impact on eukaryogenesis
Structural and Chemical Biology of Terpenoid Cyclases
Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species.
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