Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.

@article{Lewin2011SynthesisOA,
  title={Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.},
  author={Guy Lewin and Narayan Bhat Shridhar and Genevi{\`e}ve Aubert and Sylviane Thoret and Jo{\"e}lle Dubois and Thierry Cresteil},
  journal={Bioorganic & medicinal chemistry},
  year={2011},
  volume={19 1},
  pages={186-96}
}
Eighteen new analogues of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxy-flavone, a potent natural cytotoxic and antimitotic flavone, were synthesized from calycopterin, the major flavonoid of Calycopteris floribunda Lamk., a traditional Asian medicinal plant. One of them, the 3'-amino substituted analogue, displayed almost the same activity as the reference compound. Pharmacomodulation at C-3' on the B-ring, and at C-5,6,7 and 8 on the A-ring allowed to refine structure-activity relationships within… CONTINUE READING