Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action.

@article{Bragagni2017SynthesisOA,
  title={Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action.},
  author={Marco Bragagni and Fabrizio Carta and Sameh M. Osman and Zeid Abdullah Alothman and Claudiu T. Supuran},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  year={2017},
  volume={32 1},
  pages={701-706}
}
Acridine orange (AO) a fluorescent cationic dye used for the management of human musculoskeletal sarcomas, due to its strong tumoricidal action and accumulation in the acidic environment typical of hypoxic tumors, was used for the preparation of a primary sulfonamide derivative. The rationale behind the drug design is the fact that hypoxic, acidic tumors… CONTINUE READING