Synthesis of aminated poly(1-vinylimidazole) for a new pH-sensitive DNA carrier.

S. Asayama; T. Sekine; H. Kawakami; S. Nagaoka

DOI:10.1093/NASS/NRM167

Corpus ID: 23204278

Synthesis of aminated poly(1-vinylimidazole) for a new pH-sensitive DNA carrier.

@article{Asayama2007SynthesisOA,
  title={Synthesis of aminated poly(1-vinylimidazole) for a new pH-sensitive DNA carrier.},
  author={S. Asayama and T. Sekine and H. Kawakami and S. Nagaoka},
  journal={Nucleic acids symposium series},
  year={2007},
  volume={51},
  pages={
          333-4
        }
}

S. Asayama, T. Sekine, +1 author S. Nagaoka

Published 2007

Chemistry, Medicine

Nucleic acids symposium series

The poly(1-vinylimidazole) (PVIm) with aminoethyl groups has been synthesized as a new pH-sensitive DNA carrier. The resulting aminated PVIm (PVIm-NH2) was water-soluble in spite of the deprotonation of the imidazole groups at physiological pH, as determined by acid-base titration and solution turbidity measurement. Hemolysis assay showed the PVIm-NH2 enhanced membrane disruptive ability at endosomal pH, owing to the protonation of the imidazole groups with a pKa value around 6.0. Agarose gel… CONTINUE READING

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