Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors.

@article{Ohara2008SynthesisOA,
  title={Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors.},
  author={Chiaki Ohara and R. Takahashi and T. Miyagawa and Y. Yoshimura and A. Kato and I. Adachi and H. Takahata},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2008},
  volume={18 6},
  pages={
          1810-3
        }
}
A highly practicable synthesis of both enantiomers of 3-hydroxypipecolic acid derivatives 1, 2, 3, 4 is described. Screening of these molecules for glycosidase inhibition has been examined. Compound 3 was shown to be a potent inhibitor of beta-N-acetylglucosaminidase as well as Escherichia coli beta-glucuronidase. 
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