Synthesis of adenophostin A and congeners modified at glucose

@article{Marwood2000SynthesisOA,
  title={Synthesis of adenophostin A and congeners modified at glucose},
  author={R. D. Marwood and A. Riley and D. Jenkins and B. L. Potter},
  journal={Journal of The Chemical Society-perkin Transactions 1},
  year={2000},
  pages={1935-1947}
}
  • R. D. Marwood, A. Riley, +1 author B. L. Potter
  • Published 2000
  • Chemistry
  • Journal of The Chemical Society-perkin Transactions 1
  • A convergent route is described to the super-potent 1D-myo-inositol 1,4,5-trisphosphate receptor agonist adenophostin A (2) and analogues 5 and 7, in which the glucose bisphosphate unit is replaced by corresponding xylose bisphosphate and mannose bisphosphate units respectively. Adenosine was converted into its 2′,3′-O-p-methoxybenzylidene derivative 8ab, which was selectively N6-dimethoxytritylated by a transient protection method. 5′-O-Benzylation followed by reductive acetal cleavage gave… CONTINUE READING
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