Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

@article{Powner2009SynthesisOA,
  title={Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions},
  author={Matthew W. Powner and B{\'e}atrice Gerland and John D. Sutherland},
  journal={Nature},
  year={2009},
  volume={459},
  pages={239-242}
}
At some stage in the origin of life, an informational polymer must have arisen by purely chemical means. According to one version of the ‘RNA world’ hypothesis this polymer was RNA, but attempts to provide experimental support for this have failed. In particular, although there has been some success demonstrating that ‘activated’ ribonucleotides can polymerize to form RNA, it is far from obvious how such ribonucleotides could have formed from their constituent parts (ribose and nucleobases… 
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