Synthesis of a tetrahydroimidazo- [2’,1’:2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity

@inproceedings{Amat2009SynthesisOA,
  title={Synthesis of a tetrahydroimidazo- [2’,1’:2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity},
  author={Mercedes Amat and Andrea K{\"o}v{\'e}r and Danica Jokic and Oscar Iv{\'a}n Perlaza Lozano and Maria P{\'e}rez and Nicola Landoni and Fabiana Subrizi and Jes{\'u}s Silva Bautista and Joan Bosch},
  year={2009}
}
A straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported. 

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