Synthesis of a precursor dipeptide of thymopentin in organic solvents by an enzymatic method.

@article{Li2008SynthesisOA,
  title={Synthesis of a precursor dipeptide of thymopentin in organic solvents by an enzymatic method.},
  author={Shijun Li and Yi Zhao and Yi-Bing Huang and Gui Gao and Dai-Hui Zhang and Li Xu and Gang Li and Xue-zhong Zhang},
  journal={Preparative biochemistry & biotechnology},
  year={2008},
  volume={38 2},
  pages={158-71}
}
The protease-catalyzed, kinetically controlled synthesis of a precursor dipeptide of thymopentin(TP-5), Z-Arg-Lys-NH2 in organic solvents was studied. Z-Arg-OMe was used as the acyl donor and Lys-NH2 was used as the nucleophile. An industrial alkaline protease alcalase and trypsin were used to catalyze the synthesis of the target dipeptide in water-organic… CONTINUE READING