Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity.

Abstract

Many protein-protein interactions in cells are mediated by functional domains that recognize and bind to motifs containing phosphorylated serine and threonine residues. To create small molecules that inhibit such interactions, we developed methodology for the synthesis of a prodrug that generates a phosphoserine peptidomimetic in cells. For this study, we… (More)
DOI: 10.1016/j.chembiol.2012.05.011

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Cite this paper

@article{Arrendale2012SynthesisOA, title={Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity.}, author={Allison Arrendale and Keunho Kim and Jun Young Choi and Wei Li and Robert L. Geahlen and Richard F. Borch}, journal={Chemistry & biology}, year={2012}, volume={19 6}, pages={764-71} }