Synthesis of a new water-soluble oligo(phenylenevinylene) containing a tyrosine moiety for tyrosinase activity detection.

Abstract

A new water-soluble oligo(phenylenevinylene) containing a tyrosine unit (OPV-Tyr) was synthesized as a fluorescent probe to optically detect tyrosinase activity. Upon the addition of tyrosinase, the tyrosine moiety was oxidized to quinone, which quenched the fluorescence of OPV-Tyr via intramolecular electron transfer from the phenylenevinylene unit to the quinone site. OPV-Tyr was elaborated to detect tyrosinase activity both in aqueous buffer solution and in agarose gel.

DOI: 10.1021/ol802210s

Cite this paper

@article{Feng2008SynthesisOA, title={Synthesis of a new water-soluble oligo(phenylenevinylene) containing a tyrosine moiety for tyrosinase activity detection.}, author={Xuli Feng and Fude Feng and Minghui Yu and Fang He and Qingling Xu and Hongwei Tang and Shu Wang and Yuliang Li and Daoben Zhu}, journal={Organic letters}, year={2008}, volume={10 23}, pages={5369-72} }