Synthesis of a new Ni-phenanthroline complex and its application as an electrochemical probe for detection of nucleic acid.

@article{Qiu2011SynthesisOA,
  title={Synthesis of a new Ni-phenanthroline complex and its application as an electrochemical probe for detection of nucleic acid.},
  author={Bin Qiu and Longhua Guo and Chunhua Guo and Zhiyong Guo and Zhenyu Lin and Guonan Chen},
  journal={Biosensors & bioelectronics},
  year={2011},
  volume={26 5},
  pages={
          2270-4
        }
}
A new DNA sensor using a nickel(II) phenanthroline complex ([Ni(phen)(2)PHPIP]·2ClO(4)) as the electrochemical probe was developed. The sensor is very sensitive and selective for calf thymus DNA (ctDNA) detection in aqueous medium. The Ni-phenanthroline probe was synthesized by a two-step preparation using p-hydroxy-phenylimidazo-1,10-phenanthroline (PHPIP) as the ligand and characterized with IR, UV and MS. Some interesting electrochemical properties of the Ni-complex and the interactions of… CONTINUE READING