Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization.

@article{Hamamoto2011SynthesisOA,
  title={Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization.},
  author={Toshimasa Hamamoto and Masahiko Sisido and Takashi Ohtsuki and Masumi Taki},
  journal={Chemical communications},
  year={2011},
  volume={47 32},
  pages={9116-8}
}
By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.