Synthesis of a FTO inhibitor with anticonvulsant activity.

@article{Zheng2014SynthesisOA,
  title={Synthesis of a FTO inhibitor with anticonvulsant activity.},
  author={Guanqun Zheng and Thomas Cox and Leah Tribbey and Gloria Z Wang and Paulina Iacoban and Matthew E Booher and Gregory J. Gabriel and Lu Zhou and Nancy S. Bae and Joie Rowles and Chuan He and M. J. Olsen},
  journal={ACS chemical neuroscience},
  year={2014},
  volume={5 8},
  pages={658-65}
}
We describe the rationale for and the synthesis of a new class of compounds utilizing a modular approach that are designed to mimic ascorbic acid and to inhibit 2-oxoglutarate-dependent hydroxylases. Preliminary characterization of one of these compounds indicates in vivo anticonvulsant activity (6 Hz mouse model) at nontoxic doses, inhibition of the 2-oxoglutarate-dependent hydroxylase FTO, and expected increase in cellular N(6)-methyladenosine. This compound is also able to modulate various… CONTINUE READING
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