Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent

@article{Berndt2008SynthesisOA,
  title={Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent},
  author={U. E. C. Berndt and Christian Stanetty and T. Wanek and C. Kuntner and J. Stanek and M. Berger and Martin Bauer and G. Henriksen and Hans-Juergen Wester and H. Kvaternik and P. Angelberger and C. Noe},
  journal={Journal of Labelled Compounds and Radiopharmaceuticals},
  year={2008},
  volume={51},
  pages={137-145}
}
  • U. E. C. Berndt, Christian Stanetty, +9 authors C. Noe
  • Published 2008
  • Chemistry
  • Journal of Labelled Compounds and Radiopharmaceuticals
  • This study describes the synthesis of a fluoroethylated derivative of [N-methyl-11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C]6-OH-BTA-1; Pittsburgh Compound B (PIB)), an already established amyloid imaging agent. The [11C]methylamino group of [11C]6-OH-BTA-1 was formally replaced by a fluoroethyl group in a cold synthesis via N-alkylation of N-Boc-2-(4′-aminophenyl)-6-(methoxyethoxymethoxy)benzothiazole with fluoroethyl tosylate. Subsequent deprotection gave the target compound 2… CONTINUE READING
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