• DOI:10.1002/JLCR.1476
Corpus ID: 4270358

Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent

@article{Berndt2008SynthesisOA,
  title={Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent},
  author={U. E. C. Berndt and Christian Stanetty and T. Wanek and C. Kuntner and J. Stanek and M. Berger and Martin Bauer and G. Henriksen and Hans-Juergen Wester and H. Kvaternik and P. Angelberger and C. Noe},
  journal={Journal of Labelled Compounds and Radiopharmaceuticals},
  year={2008},
  volume={51},
  pages={137-145}
}

U. E. C. Berndt, Christian Stanetty, +9 authors C. Noe

Published 2008

Chemistry

Journal of Labelled Compounds and Radiopharmaceuticals

This study describes the synthesis of a fluoroethylated derivative of [N-methyl-11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C]6-OH-BTA-1; Pittsburgh Compound B (PIB)), an already established amyloid imaging agent. The [11C]methylamino group of [11C]6-OH-BTA-1 was formally replaced by a fluoroethyl group in a cold synthesis via N-alkylation of N-Boc-2-(4′-aminophenyl)-6-(methoxyethoxymethoxy)benzothiazole with fluoroethyl tosylate. Subsequent deprotection gave the target compound 2… CONTINUE READING

View via Publisher

neurocluster-db.meduniwien.ac.at

Save to Library

Create Alert

Cite

Launch Research Feed