Synthesis of Triterpene A-Condensed Azoles

@article{Galaiko2014SynthesisOT,
  title={Synthesis of Triterpene A-Condensed Azoles},
  author={N. V. Galaiko and A. V. Nazarov and I. A. Tolmacheva and P. Slepukhin and Yu. B. Vikharev and O. Maiorova and V. V. Grishko},
  journal={Chemistry of Heterocyclic Compounds},
  year={2014},
  volume={50},
  pages={65-75}
}
Lupane and 18αH-oleanane α-hydroximino ketones were used to synthesize derivatives condensed at ring A with a substituted azole fragment, namely, C(2)–C(3)-fused oxazoles and 1,2,3-triazoles. Triterpene isoxazoles fused at the C(1)–C(2) bond are described for the first time. An optimized method was proposed for the synthesis of unsubstituted 1,2,3-triazoles, displaying cytotoxic activity (IC50 8.4-40.7 μM) relative to rhabdomyosarcoma, lung carcinoma, and MS melanoma cell lines. 
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