Synthesis of Triterpene A-Condensed Azoles

  title={Synthesis of Triterpene A-Condensed Azoles},
  author={N. V. Galaiko and A. V. Nazarov and I. A. Tolmacheva and P. Slepukhin and Yu. B. Vikharev and O. Maiorova and V. V. Grishko},
  journal={Chemistry of Heterocyclic Compounds},
Lupane and 18αH-oleanane α-hydroximino ketones were used to synthesize derivatives condensed at ring A with a substituted azole fragment, namely, C(2)–C(3)-fused oxazoles and 1,2,3-triazoles. Triterpene isoxazoles fused at the C(1)–C(2) bond are described for the first time. An optimized method was proposed for the synthesis of unsubstituted 1,2,3-triazoles, displaying cytotoxic activity (IC50 8.4-40.7 μM) relative to rhabdomyosarcoma, lung carcinoma, and MS melanoma cell lines. 
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  • C. Ross
  • Medicine
  • The Dental register
  • 1869
of the Russian Academy of Sciences "Basic Sciences for Medicine" (grant 12-R-3-1009) and the Russian Foundation for Basic Research (grant 12-03-31060_mol_a)
  • [Russ. Chem. Bul., 50,
  • 2001