Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities

@article{Bara2019SynthesisOT,
  title={Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities},
  author={J. Bar{\'u}a and M. de la Cruz and N. De Pedro and B. Cautain and R. Hermosa and R. Cardoza and S. Guti{\'e}rrez and E. Monte and F. Vicente and I. G. Collado},
  journal={Molecules},
  year={2019},
  volume={24}
}
Trichothecene mycotoxins are recognized as highly bioactive compounds that can be used in the design of new useful bioactive molecules. In Trichoderma brevicompactum, the first specific step in trichothecene biosynthesis is carried out by a terpene cyclase, trichodiene synthase, that catalyzes the conversion of farnesyl diphosphate to trichodiene and is encoded by the tri5 gene. Overexpression of tri5 resulted in increased levels of trichodermin, a trichothecene-type toxin, which is a valuable… Expand
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References

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