Corpus ID: 93665604

Synthesis of Thio Derivatives of Phenobarbital and Its N-Methyl Derivatives

@article{StasiewiczUrban2004SynthesisOT,
  title={Synthesis of Thio Derivatives of Phenobarbital and Its N-Methyl Derivatives},
  author={A. Stasiewicz-Urban and M. Kubaszek and M. Żylewski and M. Cegła and J. Bojarşki},
  journal={Polish Journal of Chemistry},
  year={2004},
  volume={78},
  pages={2105-2115}
}
Differently substituted thio derivatives of phenobarbital and its N-mono- and N,N'-dimethyl derivatives were obtained by thionation of respective substrates with Lawesson's reagent. The structure of the products not described in the literature was confirmed by spectral and elemental analyses. The spectral properties allow to differentiate between positional isomers of the products. 
The influence of sulfur substituents on the molecular geometry and packing of thio derivatives of N-methylphenobarbital.