Synthesis of Schiff bases of benzofuran with potential biological activity.

@article{Rahman1976SynthesisOS,
  title={Synthesis of Schiff bases of benzofuran with potential biological activity.},
  author={A. Habeebur Rahman and E M Ismail},
  journal={Arzneimittel-Forschung},
  year={1976},
  volume={26 5},
  pages={756-9}
}
Reduction of 5-methoxy-6-formyl(Ia)- and 5-formyl-6-methoxy-2,3-diphenylbenzofuran (IVa) yielded 6- and 5-methyl derivatives Ib and IVb, respectively. Oxidation, hydrolysis and demethylation of Ib and IVb gave 2,2-dihydroxy-4-methyl-)IIc)-and2,4-dihydroxy-5-methylbenzofuran )Vc). The carboxamides Ie and IVe were obtained from the oximes Ic and IVc via the cyano derivatives Id and IVd. By condensation of the aldehydes If, IVf and VII with primary amines the corresponding Schiff bases (IIIa--c… CONTINUE READING