Synthesis of Ribavirin, Tecadenoson, and Cladribine by Enzymatic Transglycosylation

  title={Synthesis of Ribavirin, Tecadenoson, and Cladribine by Enzymatic Transglycosylation},
  author={Marco Rabuffetti and Teodora Bavaro and Riccardo Semproli and Giulia Cattaneo and Michela Massone and Carlo F. Morelli and Giovanna Speranza and Daniela Ubiali},
Despite the impressive progress in nucleoside chemistry to date, the synthesis of nucleoside analogues is still a challenge. Chemoenzymatic synthesis has been proven to overcome most of the constraints of conventional nucleoside chemistry. A purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP) has been used herein to catalyze the synthesis of Ribavirin, Tecadenoson, and Cladribine, by a “one-pot, one-enzyme” transglycosylation, which is the transfer of the carbohydrate moiety from… 

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