Synthesis of QS-21-xylose: establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine.

@article{Deng2008SynthesisOQ,
  title={Synthesis of QS-21-xylose: establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine.},
  author={Kai Deng and M. Adams and Payal Damani and P. Livingston and G. Ragupathi and D. Gin},
  journal={Angewandte Chemie},
  year={2008},
  volume={47 34},
  pages={
          6395-8
        }
}
  • Kai Deng, M. Adams, +3 authors D. Gin
  • Published 2008
  • Medicine
  • Angewandte Chemie
    • The success of antitumor and antiviral vaccines often requires the use of an adjuvant, a substance that is itself not necessarily immunogenic but significantly enhances the immune response of a patient to a coadministered antigen.[1] The adjuvant of choice in many recent immunotherapeutic advances against cancer,[2] human immunodeficiency virus,[3, 4] and malaria[5, 6] is the natural product saponin QS-21.[7] Extensive studies in the development of conjugate cancer vaccines demonstrated the… CONTINUE READING
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    47 Citations
    Background Citations
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    Methods Citations
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    47 Citations
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    Design, synthesis and evaluation of optimized saponin variants derived from the vaccine adjuvant QS-21
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    Synthesis of QS-21-based immunoadjuvants.
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    Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21.
    • 4
    Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol.
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    Synthesis and preclinical evaluation of QS-21 variants leading to simplified vaccine adjuvants and mechanistic probes.
    • 40
    Preclinical evaluation of the synthetic adjuvant SQS-21 and its constituent isomeric saponins.
    • 31

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