Synthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancement

@article{Shadrack2015SynthesisOP,
  title={Synthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancement},
  author={D. M. Shadrack and E. Mubofu and Stephen S Nyandoro},
  journal={International Journal of Molecular Sciences},
  year={2015},
  volume={16},
  pages={26363 - 26377}
}
  • D. M. Shadrack, E. Mubofu, Stephen S Nyandoro
  • Published 2015
  • Chemistry, Medicine
  • International Journal of Molecular Sciences
  • The biomedical potential of flavonoids is normally restricted by their low water solubility. However, little has been reported on their encapsulation into polyamidoamine (PAMAM) dendrimers to improve their biomedical applications. Generation four (G4) PAMAM dendrimer containing ethylenediaminetetraacetic acid core with acrylic acid and ethylenediamine as repeating units was synthesized by divergent approach and used to encapsulate a flavonoid tetramethylscutellarein (TMScu, 1) to study its… CONTINUE READING
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    References

    SHOWING 1-10 OF 38 REFERENCES
    Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers.
    • 350
    • Highly Influential
    • PDF
    [The effect of polyamidoamine (PAMAM) dendrimers on the solubility and pharmacokinetics of breviscapine].
    • J. Lu, Z. Wu, Q. Ping
    • Chemistry, Medicine
    • Yao xue xue bao = Acta pharmaceutica Sinica
    • 2009
    • 2
    Dendimer-mediated solubilization, formulation development and in vitro-in vivo assessment of piroxicam.
    • 68
    • Highly Influential
    Formulation and characterization of polyphenol-loaded lipid nanocapsules.
    • 164
    DENDRIMER APPLICATIONS – A REVIEW
    • 37
    • Highly Influential
    Novel self-assembled core-shell nanoparticles based on crystalline amorphous moieties of aliphatic copolyesters for efficient controlled drug release.
    • S. Papadimitriou, D. Bikiaris
    • Materials Science, Medicine
    • Journal of controlled release : official journal of the Controlled Release Society
    • 2009
    • 109
    • Highly Influential