Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries

@article{Hbert1994SynthesisON,
  title={Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries},
  author={N. H{\'e}bert and P. Davis and E. DeBaets and O. Acevedo},
  journal={Tetrahedron Letters},
  year={1994},
  volume={35},
  pages={9509-9512}
}
Abstract A series of N-substituted DMT-hydroxymethylpyrrolidinol phosphoramidites has been prepared from trans-4-hydroxyproline. These can be coupled in high yield and purity using automated synthesis techniques, allowing a wide range of functionalities to be introduced into phosphodiester oligomers. 
Solid-phase synthesis of a library of functionalized aminodiol scaffolds.
Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone.
  • P. Lin, A. Ganesan
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1998
...
1
2
3
...