Synthesis of Monomethylated Dimeric Benzopyrans as HIV-1 and HIV-2 Inhibitors. Part 1.

@article{Chavda2003SynthesisOM,
  title={Synthesis of Monomethylated Dimeric Benzopyrans as HIV-1 and HIV-2 Inhibitors. Part 1.},
  author={M. Chavda and Denish C. Karia and Anamik K. Shah},
  journal={ChemInform},
  year={2003},
  volume={34}
}
Warfarin and its analogs have been identifi ed for structure based des ign of non peptidic HIV protease inhi bitors and 4-hydroxycoumarin was identified as a lead structure l . The cal onolides bearing coumarin features have also been modified for anti -HIV acti vity". The 4-hydroxypyrone ring was suggested as a pharmacophore based on its crystal structure. The sul fonamide containing 4-hydroxycoumarins and 4hydroxy-2-pyrones were studied as protease inhibi tory template. Simultaneously number… Expand

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