Synthesis of MR-49, a deiodinated analog of tetraiodothyroacetic acid (tetrac), as a novel pro-angiogenesis modulator.

Abstract

The tyrosine-based hormones 3,3',5-triiodo-l-thyronine (l-T3) and l-thyroxine (l-T4) that are produced by the thyroid gland control metabolic functions. Iodothyronine deiodinase enzymes convert l-T4 to l-T3, the form of thyroid hormone critical to genomic actions within cells and regulation of metabolism, and to reverse-l-T3, a hormone isoform that is… (More)
DOI: 10.1016/j.bmcl.2016.06.064

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Cite this paper

@article{Rajabi2016SynthesisOM, title={Synthesis of MR-49, a deiodinated analog of tetraiodothyroacetic acid (tetrac), as a novel pro-angiogenesis modulator.}, author={M. Rajabi and T. Sudha and Noureldien H. E. Darwish and Paul J. Davis and Shaker A. Mousa}, journal={Bioorganic & medicinal chemistry letters}, year={2016}, volume={26 16}, pages={4112-6} }