Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology.

@article{Freyne1998SynthesisOL,
  title={Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology.},
  author={Eddy J E Freyne and A Raeymaekers and M. Venet and Gerard Sanz and Walter Wouters and Roland De Coster and Jean P. Van Wauwe},
  journal={Bioorganic & medicinal chemistry letters},
  year={1998},
  volume={8 3},
  pages={267-72}
}
The synthesis of LIAZAL (compound 9, R085246) is described. LIAZAL inhibits all-trans-retinoic acid metabolism and thereby exerts retinoid-like effects in vivo.