Synthesis of L-phenylalanine analogs byRhodotorula glutinis. Bioconversion of cinnamic acids derivatives
@article{Renard2005SynthesisOL, title={Synthesis of L-phenylalanine analogs byRhodotorula glutinis. Bioconversion of cinnamic acids derivatives}, author={G. Renard and J. C. Guilleux and Clety Kwambai Bore and V. Malta-Valette and Dan A Lerner}, journal={Biotechnology Letters}, year={2005}, volume={14}, pages={673-678} }
The synthesis of L-alpha aromatic amino acids by amination of forty-one derivatives of cinnamic acid and related compounds is tested with the yeastRhodotorula glutinis.
22 Citations
Preparation of unnatural amino acids with ammonia-lyases and 2,3-aminomutases.
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This chapter discusses the biotransformations leading to various unnatural β-amino acids with phenylalanine 2,3-aminomutases using the same catalytic MIO prosthetic group.
Review: Biocatalytic transformations of ferulic acid: An abundant aromatic natural product
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In this review, the fascinating array of microbial and enzymatic transformations of ferulic acid is examined, including cinnamoyl side-chain cleavage; nonoxidative decarboxylation; mechanistic details of styrene formation; and reduction reactions.
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Tailored Mutants of Phenylalanine Ammonia‐Lyase from Petroselinum crispum for the Synthesis of Bulky l‐ and d‐Arylalanines
- Chemistry, BiologyChemCatChem
- 2018
The synergistic multiple mutations resulted in substantial substrate scope extension of PcPAL and opened up new biocatalytic routes for the synthesis of both enantiomers of valuable phenylalanine analogues, such as (5‐phenylthiophene‐2‐yl)alanines.
Influence of Tyr78-loop on phenylalanine ammonia-lyase from Anabaena variabilis
- Biology, Chemistry
- 2018
Catalytic activity of AvPAL could be improved by increasing the flexibility of Tyr78-loop through mutation on the Ser73 and Glu95 sites.
The interaction of heteroaryl-acrylates and alanines with phenylalanine ammonia-lyase from parsley.
- ChemistryChemistry
- 2006
These results can be best explained by a Friedel-Crafts-type electrophilic attack at the aromatic part of the substrates as the initial step of the PAL reaction.
Expression and Properties of the Highly Alkalophilic Phenylalanine Ammonia-Lyase of Thermophilic Rubrobacter xylanophilus
- BiologyPloS one
- 2014
The extremely high pH optimum of RxPAL can be rationalized by a three-dimensional homology model indicating possible disulfide bridges, extensive salt-bridge formation and an excess of negative electrostatic potential on the surface.
Chemoenzymatic One-Pot Synthesis of Enantiopure L-Arylalanines from Arylaldehydes
- Chemistry
- 2006
Various enantiopure L-arylalanines can be prepared from the corresponding arylaldehydes in one-pot fashion by a combination of chemical and enzymatic reactions. The reagents used were…
Saturation Mutagenesis for Phenylalanine Ammonia Lyases of Enhanced Catalytic Properties
- Biology, ChemistryBiomolecules
- 2020
Saturation mutagenesis at key residue I460 was performed in order to identify PcPAL variants of enhanced activity or to validate the superior catalytic properties of the rationally explored I460V P cPAL compared with the other possible mutant variants.
Fluorescent enzyme-coupled activity assay for phenylalanine ammonia-lyases
- Biology, ChemistryScientific reports
- 2020
The developed procedure provides a facile tool for the efficient activity screens of large mutant libraries of PALs in presence of non-natural substrates of interest, being essential for the substrate-specificity modifications/tailoring of PAL's through directed evolution-based protein engineering.
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