Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents.

Abstract

The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures… (More)
DOI: 10.3390/molecules21081046

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