Synthesis of Histone Deacetylases Inhibitor and Activity in Vitro

@inproceedings{Kuang2015SynthesisOH,
  title={Synthesis of Histone Deacetylases Inhibitor and Activity in Vitro},
  author={Baoping Kuang and Hui Zhang and Zhihang Shang},
  year={2015}
}
Multi-drug resistance (MDR) is an important element which leads to ineffectiveness of chemotherapeutics. The discovery of histone acetylase's unusual activities in tumor cells provides a new area for the cure of cancer. And histone deacetylases inhibitor (HDACi) is used as a new agent in clinical therapy. New histone deacetylases inhibitors have been synthesized. All the products have been characterized by 1 H-NMR and MS. The activities in vitro effects on the title compounds were examined… CONTINUE READING

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