Synthesis of Glc1Man9-Glycoprotein Probes by a Misfolding/Enzymatic Glucosylation/Misfolding Sequence.

@article{Izumi2016SynthesisOG,
  title={Synthesis of Glc1Man9-Glycoprotein Probes by a Misfolding/Enzymatic Glucosylation/Misfolding Sequence.},
  author={Masayuki Izumi and Yukiho Oka and Ryo Okamoto and Akira Seko and Yoichi Takeda and Yukishige Ito and Yasuhiro Kajihara},
  journal={Angewandte Chemie},
  year={2016},
  volume={55 12},
  pages={3968-71}
}
Glycoproteins in non-native conformations are often toxic to cells and may cause diseases, thus the quality control (QC) system eliminates these unwanted species. Lectin chaperone calreticulin and glucosidase II, both of which recognize the Glc1 Man9 oligosaccharide on glycoproteins, are important components of the glycoprotein QC system. Reported herein is… CONTINUE READING