Synthesis of Gemcitabine-(C4-amide)-[anti-HER2/neu] Utilizing a UV-Photoactivated Gemcitabine Intermediate: Cytotoxic Anti-Neoplastic Activity against Chemotherapeutic-Resistant Mammary Adenocarcinoma SKBr-3.

@article{Coyne2012SynthesisOG,
  title={Synthesis of Gemcitabine-(C4-amide)-[anti-HER2/neu] Utilizing a UV-Photoactivated Gemcitabine Intermediate: Cytotoxic Anti-Neoplastic Activity against Chemotherapeutic-Resistant Mammary Adenocarcinoma SKBr-3.},
  author={Cody P. Coyne and Toni Jones and Ryan Bear},
  journal={Journal of cancer therapy},
  year={2012},
  volume={3 5A},
  pages={689-711}
}
Gemcitabine is a pyrimidine nucleoside analog that becomes triphosphorylated intracellularly where it competitively inhibits cytidine incorporation into DNA strands. Another mechanism-of-action of gemcitabine (diphosphorylated form) involves irreversible inhibition of the enzyme ribonucleotide reductase thereby preventing deoxyribonucleotide synthesis. Functioning as a potent chemotherapeutic gemcitabine promote decreases in neoplastic cell proliferation and apoptosis which is frequently found… CONTINUE READING
Highly Cited
This paper has 20 citations. REVIEW CITATIONS
8 Extracted Citations
121 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-8 of 8 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 121 references

Synthesis of Epirubicin-(C3-amide)-[Anti-HER2/neu] utilizing a UV-Photoactivated Epirubicin Intermediate

  • C. P. Coyne, T. Jones, R. Bear
  • Cancer Biotherapy and Radiopharmaceuticals, Vol…
  • 2012
Highly Influential
10 Excerpts

Similar Papers

Loading similar papers…