Synthesis of D-labeled naphthyliodoacetamide and application to quantitative peptide analysis by isotope differential mass spectrometry.

@article{Niwayama2006SynthesisOD,
  title={Synthesis of D-labeled naphthyliodoacetamide and application to quantitative peptide analysis by isotope differential mass spectrometry.},
  author={S. Niwayama and S. Kurono and Hanjoung Cho and H. Matsumoto},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2006},
  volume={16 23},
  pages={
          6054-7
        }
}
D-labeled and -unlabeled N-beta-naphthyliodoacetamides have been synthesized for specific modification of the sulfhydryl groups of cysteine residues in proteins or peptides, and have been applied to quantitative analysis of several peptides. A combination of these reagents, coupled with mass spectrometry, is anticipated to serve as a useful tool for quantitative analysis of peptides and hence proteins. 
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