Synthesis of Commercial Phosphodiesterase(V) Inhibitors

@article{Dunn2005SynthesisOC,
  title={Synthesis of Commercial Phosphodiesterase(V) Inhibitors},
  author={P. Dunn},
  journal={Organic Process Research \& Development},
  year={2005},
  volume={9},
  pages={88-97}
}
  • P. Dunn
  • Published 2005
  • Chemistry
  • Organic Process Research & Development
The literature syntheses (including patents) of three commercial phosphodiesterase(V) (PDE5) inhibitors (sildenafil, vardenafil, and tadalafil) are reviewed with particular emphasis on large-scale manufacture. For each of these compounds, some impressive chemical development work has been reported. 

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World Patent , WO 04 / 011463 . Scheme 14 . Building blocks for tadalafil Scheme 15