Synthesis of Commercial Phosphodiesterase(V) Inhibitors
@article{Dunn2005SynthesisOC, title={Synthesis of Commercial Phosphodiesterase(V) Inhibitors}, author={Peter James Dunn}, journal={Organic Process Research \& Development}, year={2005}, volume={9}, pages={88-97} }
The literature syntheses (including patents) of three commercial phosphodiesterase(V) (PDE5) inhibitors (sildenafil, vardenafil, and tadalafil) are reviewed with particular emphasis on large-scale manufacture. For each of these compounds, some impressive chemical development work has been reported.
57 Citations
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World Patent , WO 04 / 011463 . Scheme 14 . Building blocks for tadalafil Scheme 15