Synthesis of Commercial Phosphodiesterase(V) Inhibitors

@inproceedings{Dunn2005SynthesisOC,
  title={Synthesis of Commercial Phosphodiesterase(V) Inhibitors},
  author={Peter James Dunn},
  year={2005}
}
  • Peter James Dunn
  • Published 2005
  • Chemistry
  • The literature syntheses (including patents) of three commercial phosphodiesterase(V) (PDE5) inhibitors (sildenafil, vardenafil, and tadalafil) are reviewed with particular emphasis on large-scale manufacture. For each of these compounds, some impressive chemical development work has been reported. 

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    Chinese Patent CN 99 - 111153 ,

    • D. Yang, H. Wang, H. Shi
    • 2001

    World Patent , WO 04 / 011463 . Scheme 14 . Building blocks for tadalafil Scheme 15

    • M. W. Orme, J. C. Sawyer, M. J. Martinelli, C. W. Doecke, J. M. Pawlak