Synthesis of Bulky @-Lactams for Inhibition of Cell Surface

Abstract

Procedures are described for the preparation of a series of compounds consisting of methicillin linked to 0-cyclodextrin through variable hydrophilic linkers. P-Cyclodextrin was coupled to the antibiotic methicillin to prevent the antibiotic from permeating the outer membranes of bacteria. Stoichiometric oxidation of the P-cyclodextrin with sodium… (More)

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