Synthesis of Bicyclo[4.1.0]heptenes via Palladium-Catalyzed Intramolecular Coupling-Cyclization of 3-(Cyclohexa-2,4-dienyl)pentane-2,4-dione with â-Styryl Bromides†

Abstract

Palladium-catalyzed intramolecular coupling-cyclization of 3-(cyclohexa-2,4-dienyl)pentane-2,4-dione with â-styryl bromides proceeds in regioand stereoselective fashions to give 2-styryl-substituted bicyclo[4.1.0]hept-3-enes in good yields. The formation of the bicyclo[4.1.0]hept-3-enes was rationalized by starting with oxidative addition of Pd(PPh3)4 to… (More)

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2 Figures and Tables