Synthesis of Anthracyclines Related to Daunomycin

  title={Synthesis of Anthracyclines Related to Daunomycin},
  author={Gareth John Thomas},
The significant antitumour activity of the anthracyclines has stimulated considerable interest in the synthesis of new analogues which have improved therapeutic properties. Synthetic approaches to the tetracyclic aglycone moiety have been based on Friedel-Crafts acylations, base catalysed annulations and Diels-Alder reactions. Whereas the majority of published syntheses lead to racemic aglycones some strategies make use of homochiral synthons obtained by resolution or asymmetric synthesis, or… CONTINUE READING