Synthesis of Acridine-based DNA Bis-intercalating Agents

  title={Synthesis of Acridine-based DNA Bis-intercalating Agents},
  author={Gerard P. Moloney and David P. Kelly and P W Mack},
Methods for the synthesis of N1, N8-bis(9-acridinyl)-N4-(4-hydroxybenzyl)spermidine and N1, N7-(hydroxybenzyl)-bis-(3-aminopropyl)amine were investigated. Thus monocyanoethylation of 4-methoxybenzylamine followed by treatment with 4chlorobutyronitrile gave the dinitrile N-(2-cyanoethyl)-N-(3-cyanopropyl)-4-methoxybenzylamine. Subsequent in situ reduction with lithium aluminium hydride gave the corresponding diamine. Biscyanoethylation of 4-methoxybenzylamine with 2 mole of acrylonitrile… CONTINUE READING


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