Synthesis of A/B-ring partial analogs of bruceantin as potential antimalarial agents.

@article{Guo2005SynthesisOA,
  title={Synthesis of A/B-ring partial analogs of bruceantin as potential antimalarial agents.},
  author={Zizao Guo and Suryanarayana Vangapandu and Abraham Nimrod and Larry A Walker and Robert D. Sindelar},
  journal={Medicinal chemistry (Shariqah (United Arab Emirates))},
  year={2005},
  volume={1 1},
  pages={3-11}
}
Bruceantin (1), a classical quassinoid with the highest reported antimalarial activity among the quassinoids examined thus far, was selected as a natural product lead for the design of a series of A/B-ring analogs. A viable strategy for the synthesis of the series was developed. The functionalized A-ring and the C-15 ester moiety in bruceantin are… CONTINUE READING