Synthesis of 9-Fluorenemethyl Boranophosphonodiphosphate Via an H-Phosphonate Approach

@article{Liu2007SynthesisO9,
  title={Synthesis of 9-Fluorenemethyl Boranophosphonodiphosphate Via an H-Phosphonate Approach},
  author={Hongyan Liu and S. A. Nadeem Hashmi and Barbara Ramsay Shaw},
  journal={Nucleosides, Nucleotides \& Nucleic Acids},
  year={2007},
  volume={26},
  pages={1455 - 1457}
}
9-Fluorenemethyl boranophosphonate 6 and its boranophosphonodiphosphate 7 were synthesized via an H-phosphonate approach. The method is efficient for the synthesis of acyclic compounds 6 & 7 , and can be explored for the synthesis of nucleoside 5′-deoxy boranophosphonodiphosphate. 

References

SHOWING 1-6 OF 6 REFERENCES
Boranophosphate backbone: a mimic of phosphodiesters, phosphorothioates, and methyl phosphonates.
Synthesis of novel 3'-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides.
Novel 5'-O-DMT- and MMT-protected 3'-C-methylene-modified thymidine, 5-methyluridine, and 5-methylcytidine H-phosphonates 1-7 with O-methyl, fluoro, hydrogen, and O-(2-methoxyethyl) substituents at
Structural basis for activation of α‐boranophosphate nucleotide analogues targeting drug‐resistant reverse transcriptase
TLDR
Using α‐(Rp)‐boranophosphate derivatives of the clinically relevant compounds AZT and d4T, the presence of the α‐borano group improved both phosphorylation by nucleotide diphosphate kinase and inhibition of reverse transcription.
A novel selective broad-spectrum anti-DNA virus agent
TLDR
It is reported that, in mice and rabbits in vivo, the compound is effective against both local and systemic infections with herpes simplex virus type 1, including herpetic keratitis caused by a TK− mutant which is resistant to the classical anti-herpes drugs.