Synthesis of 8-heteroaryl nitroxoline analogues via one-pot sequential Pd-catalyzed coupling reactions.

@article{Brodnik2016SynthesisO8,
  title={Synthesis of 8-heteroaryl nitroxoline analogues via one-pot sequential Pd-catalyzed coupling reactions.},
  author={Helena Brodnik and Franc Po{\vz}gan and Bogdan {\vS}tefane},
  journal={Organic \& biomolecular chemistry},
  year={2016},
  volume={14 6},
  pages={
          1969-81
        }
}
A series of 8-heteroaryl substituted quinolines were prepared, either by direct C-H arylation of five-membered heteroarenes, or Pd-catalyzed coupling of organoboron reagents with bromoquinolines. The use of (benzo)thiophenyl or (benzo)furanyl boron coupling partners allowed further C-H functionalization on the five-membered heteroaryl ring with aryl bromides in one flask to access a variety of polyconjugated molecular architectures. The developed methodology represents a simple approach towards… 
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11 Citations

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