Corpus ID: 22797683

Synthesis of 7alpha-substituted derivatives of 17beta-estradiol.

  title={Synthesis of 7alpha-substituted derivatives of 17beta-estradiol.},
  author={Xiang-Rong Jiang and J. W. Sowell and B. Zhu},
  volume={71 5},
  • Xiang-Rong Jiang, J. W. Sowell, B. Zhu
  • Published 2006
  • Medicine
  • Steroids
  • Estrogen receptor (ER) pure antagonists such as ICI-182,780 (fulvestrant) are effective alternatives to tamoxifen (an ER antagonist/weak partial agonist) in the treatment of postmenopausal, receptor-positive human breast cancers. Structurally, these pure antagonists contain the basic core structure of 17beta-estradiol (E(2)) with a long side chain attached to its C-7alpha position. We explored and compared in this study various synthetic routes for preparing a number of C-7alpha-substituted… CONTINUE READING