Synthesis of 6-Trichloromethylphenanthridines by Transition Metal-Free Radical Cyclization of 2-Isocyanobiphenyls.

@article{Zhou2016SynthesisO6,
  title={Synthesis of 6-Trichloromethylphenanthridines by Transition Metal-Free Radical Cyclization of 2-Isocyanobiphenyls.},
  author={Yuhan Zhou and Changpeng Wu and Xiaoliang Dong and Jingping Qu},
  journal={The Journal of organic chemistry},
  year={2016},
  volume={81 12},
  pages={5202-8}
}
An efficient method for the synthesis of 6-trichloromethylphenanthridines by benzoyl peroxide promoted cyclization reaction of 2-isocyanobiphenyls with carbon tetrachloride is developed. A radical pathway is proposed and evidenced for the reaction mechanism. This reaction tolerates a wide range of functional groups and the resulting 6… CONTINUE READING