Synthesis of 5-phosphonate analogues of myo-inositol 1,4,5-trisphosphate : possible intracellular calcium antagonists

@inproceedings{Dreef1991SynthesisO5,
  title={Synthesis of 5-phosphonate analogues of myo-inositol 1,4,5-trisphosphate : possible intracellular calcium antagonists},
  author={C. E. Dreef and Werner Dr. Schiebler and Gijs A. van der Marel and Jacques H. van Boom},
  year={1991}
}
  • C. E. Dreef, Werner Dr. Schiebler, +1 author Jacques H. van Boom
  • Published 1991
  • Chemistry
  • Abstract The racemic 5-phosphonate analogues IV and V of myo -inositol 1,4,5-trisphosphate were readily accessible by bisphosphorylation of the common precursor 6 , removal of the p -methoxybenzyl group, phosphonylation and subsequent hydrogenolysis of the benzyl protecting groups. The methylphosphonate analogue IV acted as a calcium antagonist in permeabilized human platelets, whereas the (difluoromethyl)phosphonate V exhibited only very little antagonistic activity. 

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